The safe enterocin DD14 is a leaderless two-peptide bacteriocin with anti- clostridium perfringens activity

Highlights • Purification of enterocin DD14 produced by Enterococcus faecalis strain 14 isolated from meconium. • Biochemical and genetic characterisation of enterocin DD14. • Anti- Clostridium perfringens activity. • No cytotoxicity of enterocin DD14 towards IPEC-1 cells.

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Bibliographische Detailangaben
Veröffentlicht in:	International journal of antimicrobial agents 2017-03, Vol.49 (3), p.282-289
Hauptverfasser:	Caly, Delphine L, Chevalier, Mickaël, Flahaut, Christophe, Cudennec, Benoit, Al Atya, Ahmed Khassaf, Chataigné, Gabrielle, D'Inca, Romain, Auclair, Eric, Drider, Djamel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Bacteriocin Bridged-Ring Compounds - chemistry Bridged-Ring Compounds - isolation & purification Bridged-Ring Compounds - pharmacology Cell Line Cell Survival Clostridium perfringens Clostridium perfringens - drug effects Cytotoxicity Enterococcus faecalis Enterococcus faecalis - metabolism Epithelial Cells - drug effects Epithelial Cells - physiology Infectious Disease Life Sciences Microbial Sensitivity Tests Molecular Weight Peptides - chemistry Peptides - isolation & purification Peptides - pharmacology Sequence Analysis, DNA Sequence Homology Swine
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Beschreibung
Zusammenfassung:	Highlights • Purification of enterocin DD14 produced by Enterococcus faecalis strain 14 isolated from meconium. • Biochemical and genetic characterisation of enterocin DD14. • Anti- Clostridium perfringens activity. • No cytotoxicity of enterocin DD14 towards IPEC-1 cells.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2016.11.016