Genotype combinations of two IL4 polymorphisms influencing IL-4 plasma levels are associated with different risks of severe malaria in the Malian population

Genotype combinations of two IL4 polymorphisms influencing IL-4 plasma levels are associated with different risks of severe malaria in the Malian population

We have previously found that children heterozygous for IL4 variable-number tandem repeat (VNTR) (rs8179190) or IL4-33 (rs2070874) variants were at risk for severe malaria (SM), whereas homozygous children were protected suggesting a complex genetic control. Hence, to dissect this complex genetic co...

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Veröffentlicht in:Immunogenetics (New York) 2015-06, Vol.67 (5-6), p.283-288
Hauptverfasser: Cabantous, Sandrine, Ranque, Stéphane, Poudiougou, Belco, Traore, Abdoulaye, Berbache, Sofiane, Vitte, Joana, Bongrand, Pierre, Doumbo, Ogobara, Dessein, Alain. J., Abel, Laurent, Marquet, Sandrine
Format: Artikel
Sprache:eng
Schlagworte:
Allergology
Biomedical and Life Sciences
Biomedicine
Cell Biology
Coma
Cytokines
Families & family life
Female
Gene Function
Genetic Association Studies
Genetic Predisposition to Disease
Genetics, Population
Genotype
Genotype & phenotype
Human Genetics
Humans
Immunology
Infectious diseases
Interleukin-4 - blood
Interleukin-4 - genetics
Life Sciences
Malaria
Malaria - blood
Malaria - genetics
Malaria - pathology
Male
Mali
Minisatellite Repeats - genetics
Original Paper
Parasites
Pharmacy
Plasma
Polymorphism, Single Nucleotide
Regression analysis
Risk Factors
Vector-borne diseases
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Zusammenfassung:We have previously found that children heterozygous for IL4 variable-number tandem repeat (VNTR) (rs8179190) or IL4-33 (rs2070874) variants were at risk for severe malaria (SM), whereas homozygous children were protected suggesting a complex genetic control. Hence, to dissect this complex genetic control of IL4 VNTR and IL4-33, we performed further investigation by conditional logistic regression analysis and found a strong interaction between both markers ( p  
ISSN:0093-7711
1432-1211
DOI:10.1007/s00251-015-0836-3