Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats

This study aimed to investigate effects of citrus flavanones naringenin (NAR) and hesperetin (HES) on liver antioxidant status and membrane phospholipid composition in 24-month-old rats. NAR and HES (15mg/kg) were administrated orally to male Wistar rats, once per day, for 4weeks. Control group rece...

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Veröffentlicht in:	Experimental gerontology 2016-11, Vol.84, p.49-60
Hauptverfasser:	Miler, Marko, Živanović, Jasmina, Ajdžanović, Vladimir, Oreščanin-Dušić, Zorana, Milenković, Dragan, Konić-Ristić, Aleksandra, Blagojević, Duško, Milošević, Verica, Šošić-Jurjević, Branka
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - drug effects Aging - metabolism Animals Antioxidant system Antioxidants - metabolism Citrus - chemistry Citrus flavanones Flavanones - pharmacology Food and Nutrition Gene Expression - drug effects Hesperidin - pharmacology Human health and pathology Life Sciences Lipid Peroxidation - drug effects Liver Liver - enzymology Liver - metabolism Male Old age rats Oxidative Stress - drug effects Phospholipid composition Phospholipids - chemistry Plant Oils Rats Rats, Wistar Sunflower Oil Thiobarbituric Acid Reactive Substances - analysis
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Zusammenfassung:	This study aimed to investigate effects of citrus flavanones naringenin (NAR) and hesperetin (HES) on liver antioxidant status and membrane phospholipid composition in 24-month-old rats. NAR and HES (15mg/kg) were administrated orally to male Wistar rats, once per day, for 4weeks. Control group received either vehicle (sunflower oil) or remained intact. The results showed decreased (p
ISSN:	0531-5565 1873-6815
DOI:	10.1016/j.exger.2016.08.014