A functional promoter variant in IL12B predisposes to cerebral malaria

The role of the Th1 pathway in the pathogenesis of severe malaria is unclear. We recently reported that a polymorphism with increasing IFNG transcription is associated with protection against cerebral malaria (CM). Interleukin-12 is required for Th1 cell differentiation, which is characterized by th...

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Veröffentlicht in:	Human molecular genetics 2008-07, Vol.17 (14), p.2190-2195
Hauptverfasser:	Marquet, Sandrine, Doumbo, Ogobara, Cabantous, Sandrine, Poudiougou, Belco, Argiro, Laurent, Safeukui, Innocent, Konate, Salimata, Sissoko, Sibiri, Chevereau, Estelle, Traore, Abdoulaye, Keita, Mamadou M., Chevillard, Christophe, Abel, Laurent, Dessein, Alain J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Child Cohort Studies Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Heterozygote Human protozoal diseases Humans Infectious diseases Interleukin-12 Subunit p35 - genetics Interleukin-12 Subunit p40 - genetics Life Sciences Malaria Malaria, Cerebral - genetics Medical sciences Microbiology and Parasitology Molecular and cellular biology Odds Ratio Parasitic diseases Polymorphism, Genetic Promoter Regions, Genetic Protozoal diseases Receptors, Interleukin-12 - genetics STAT4 Transcription Factor - genetics
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