Roles of adaptor proteins in regulation of bacterial proteolysis

Highlights ► Regulated degradation by ATP-dependent proteases frequently depends upon delivery of the substrate by adaptors. ► Regulation of activity of adaptors by anti-adaptors allows environmental modulation of protein turnover. ► Structural studies are uncovering how adaptors bind and hand over...

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Veröffentlicht in:	Current opinion in microbiology 2013-04, Vol.16 (2), p.140-147
Hauptverfasser:	Battesti, Aurelia, Gottesman, Susan
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Bacteria - enzymology Bacteria - metabolism Bacterial Proteins - metabolism Bacteriology Biochemistry Biochemistry, Molecular Biology cell growth eukaryotic cells Life Sciences Microbiology and Parasitology Molecular biology Pathology Peptide Hydrolases - metabolism proteasome endopeptidase complex proteinases proteins Proteolysis quality control Substrate Specificity Virology
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Zusammenfassung:	Highlights ► Regulated degradation by ATP-dependent proteases frequently depends upon delivery of the substrate by adaptors. ► Regulation of activity of adaptors by anti-adaptors allows environmental modulation of protein turnover. ► Structural studies are uncovering how adaptors bind and hand over the substrate to the protease.
ISSN:	1369-5274 1879-0364 1369-5274
DOI:	10.1016/j.mib.2013.01.002