Solvent database and in silico classification: A new methodology for solvent substitution and its application for microencapsulation process

Solvent database and in silico classification: A new methodology for solvent substitution and its application for microencapsulation process

[Display omitted] •In silico classification of solvents via Density Functional Theory (DFT).•Development of a new methodology for solvent substitution.•Substitution of dichloromethane for polycaprolactone particle formulation.

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Veröffentlicht in:International journal of pharmaceutics 2016-07, Vol.509 (1-2), p.454-464
Hauptverfasser: Levet, Amélie, Bordes, Claire, Clément, Yohann, Mignon, Pierre, Chermette, Henry, Forquet, Valérian, Morell, Christophe, Lantéri, Pierre
Format: Artikel
Sprache:eng
Schlagworte:
Analytical chemistry
Chemical Sciences
Computer Simulation
Drug Compounding - methods
Microspheres
Solvents - chemistry
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Zusammenfassung:[Display omitted] •In silico classification of solvents via Density Functional Theory (DFT).•Development of a new methodology for solvent substitution.•Substitution of dichloromethane for polycaprolactone particle formulation.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2016.05.053