Resistant depression : Switching and combining strategies of ă antidepressant medications

Switching antidepressant medication may be helpful in depressed patients ă having no benefit from the initial antidepressant treatment. ă Before considering switching strategy, the initial antidepressant ă treatment should produce no therapeutic effect after at least 4 weeks of ă administration at a...

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Veröffentlicht in:La Presse médicale (1983) 2016-03, Vol.45 (3), p.329-337
Hauptverfasser: Charpeaud, Thomas, Moliere, Fanny, Bubrovszky, Maxime, Haesebaert, Frederic, Allaïli, Najib, Bation, Remy, Nieto, Isabel, Richieri, Raphaëlle, Saba, Ghassen, Bellivier, Frank, Bennabi, Djamila, Holtzmann, Jerome, Camus, Vincent, Courtet, Philippe, Courvoisier, Pierre, d'Amato, Thierry, Doumy, Olivier, Garnier, Marion, Bougerol, Thierry, Lançon, Christophe, Haffen, Emmanuel, Leboyer, Marion, Llorca, Pierre-Michel, Vaiva, Guillaume, El-Hage, Wissam, Aouizerate, Bruno
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Sprache:eng ; fre
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Zusammenfassung:Switching antidepressant medication may be helpful in depressed patients ă having no benefit from the initial antidepressant treatment. ă Before considering switching strategy, the initial antidepressant ă treatment should produce no therapeutic effect after at least 4 weeks of ă administration at adequate dosage. ă Choosing an antidepressant of pharmacologically distinct profile fails ă to consistently demonstrate a significant superiority in terms of ă effectiveness over the switching to another antidepressant within the ă same pharmacological class. ă Augmenting SSRI/SNRIs with mirtazapine/mianserin has become the most ă recommended strategy of antidepressant combinations. ă Augmenting SSRI with tricyclic drugs is now a less recommended strategy ă of antidepressant combinations given the increased risk for the ă occurrence of pharmacokinetic drug-drug interactions and adverse ă effects.
ISSN:0755-4982
2213-0276
DOI:10.1016/j.lpm.2016.02.003