Palladium-catalysed direct arylation of heteroarenes using 1-(bromophenyl)-1,2,3-triazoles as aryl source

A variety of 1-aryl-1,2,3-triazoles containing heteroarenes at C2-, C3- or C4-positions on the aryl ring was successfully prepared via palladium-catalysed direct arylation. These couplings were performed employing 1mol% of phosphine-free Pd(OAc)2 catalyst with 1-(bromophenyl)-1,2,3-triazoles and heteroarenes as coupling partners. A wide variety of heteroarenes such as thiazoles, thiophenes, furans, pyrroles or isoxazoles was tolerated. © 2016 Elsevier Science. All rights reserved. [Display omitted]