Enantioselective Synthesis of Carbocycles and Heterocycles by Radical/Polar and Polar/Radical Cascades

Enantioselective Synthesis of Carbocycles and Heterocycles by Radical/Polar and Polar/Radical Cascades

Radically efficient: New and appealing enantioselective cyclizations leading to highly functionalized carbocycles and heterocycles have been reported (see scheme; TMS=trimethylsilyl). These methodologies, based on the cascade combination of radical and polar steps, provide alternatives to convention...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-01, Vol.52 (3), p.809-811
Hauptverfasser: Mondal, Shovan, Bertrand, Michèle P., Nechab, Malek
Format: Artikel
Sprache:eng
Schlagworte:
asymmetric synthesis
carbocycles
Cascades
Chemical Sciences
cyclization
heterocycles
Radicals
Synthesis
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Beschreibung
Zusammenfassung:Radically efficient: New and appealing enantioselective cyclizations leading to highly functionalized carbocycles and heterocycles have been reported (see scheme; TMS=trimethylsilyl). These methodologies, based on the cascade combination of radical and polar steps, provide alternatives to conventional methodologies.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201207518