Molecular mechanisms of polymyxin resistance: knowns and unknowns

Highlights • Colistin is a last-line drug against multidrug-resistant Gram-negative pathogens. • Chromosomal mutations and plasmid-borne mcr-1 remain the common modes of resistance. • Not all mechanisms mediating colistin resistance are currently known.

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Bibliographische Detailangaben
Veröffentlicht in:	International journal of antimicrobial agents 2016-12, Vol.48 (6), p.583-591
Hauptverfasser:	Baron, Sophie, Hadjadj, Linda, Rolain, Jean-Marc, Olaitan, Abiola Olumuyiwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Antibiotic resistance Colistin Drug Resistance, Bacterial - genetics Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - genetics Gram-Negative Bacteria - isolation & purification Gram-Negative Bacterial Infections - microbiology Human health and pathology Humans Infectious Disease Infectious diseases Life Sciences Lipid A modification mcr-1 Plasmids Polymyxin B Polymyxins - pharmacology
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Beschreibung
Zusammenfassung:	Highlights • Colistin is a last-line drug against multidrug-resistant Gram-negative pathogens. • Chromosomal mutations and plasmid-borne mcr-1 remain the common modes of resistance. • Not all mechanisms mediating colistin resistance are currently known.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2016.06.023