A Regional Outbreak of Clostridium difficile PCR-Ribotype 027 Infections in Southeastern France from a Single Long-Term Care Facility

OBJECTIVE To describe and analyze a large outbreak of Clostridium difficile 027 (CD-027) infections. METHODS Confirmed CD-027 cases were defined as CD infection plus real-time polymerase chain reaction assay (PCR) positive for CD-027. Clinical and microbiological data on patients with CD-027 infecti...

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Veröffentlicht in:	Infection control and hospital epidemiology 2016-11, Vol.37 (11), p.1337-1341
Hauptverfasser:	Cassir, Nadim, Delarozière, Jean-Christophe, Dubourg, Gregory, Delord, Marion, Lagier, Jean-Christophe, Brouqui, Phillipe, Fenollar, Florence, Raoult, Didier, Fournier, Pierre Edouard
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Anti-Bacterial Agents - therapeutic use Antibiotics Clostridium difficile - genetics Clostridium difficile - isolation & purification Clostridium Infections - diagnosis Clostridium Infections - epidemiology Clostridium Infections - prevention & control Cross Infection - epidemiology Cross Infection - microbiology Cross Infection - prevention & control Diarrhea Diarrhea - epidemiology Diarrhea - microbiology Diarrhea - prevention & control Disease control Disease Outbreaks Disease prevention Epidemics Female France - epidemiology Health facilities Hospitals Human health and pathology Humans Infection Control - methods Infections Infectious diseases Laboratories Life Sciences Long term health care Long-Term Care Male Mortality Nursing Original Articles Outbreaks Patients Real-Time Polymerase Chain Reaction Risk Factors Sex ratio Spatio-Temporal Analysis Surveys and Questionnaires
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Zusammenfassung:	OBJECTIVE To describe and analyze a large outbreak of Clostridium difficile 027 (CD-027) infections. METHODS Confirmed CD-027 cases were defined as CD infection plus real-time polymerase chain reaction assay (PCR) positive for CD-027. Clinical and microbiological data on patients with CD-027 infection were collected from January 2013 to December 2015 in the Provence-Alpes-Côte-d'Azur region (southeastern France). RESULTS In total, 19 healthcare facilities reported 144 CD-027 infections (112 confirmed and 32 probable CD-027 infections) during a 22-month period outbreak. Although the incidence rate per 10,000 bed days was lower in long-term care facilities (LTCFs) than in acute care facilities (0.05 vs 0.14; P
ISSN:	0899-823X 1559-6834
DOI:	10.1017/ice.2016.164