Dehydrogenative Allylic Aminations of But-3-enoic Acid Derivatives

Dehydrogenative Allylic Aminations of But-3-enoic Acid Derivatives

Abstract Two complementary Pd-catalyzed protocols enabling the γ-selective intermolecular allylic amination of but-3-enoic acid derivatives are reported. These transformations can be successfully achieved via either­ a direct Pd(II)-catalyzed protocol or by way of a one-pot Pd(II)/Pd(0)-catalyzed se...

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Veröffentlicht in:Synthesis (Stuttgart) 2016-10, Vol.48 (19), p.3400-3412
Hauptverfasser: Diamante, Daria, Gabrieli, Sara, Benincori, Tiziana, Broggini, Gianluigi, Oble, Julie, Poli, Giovanni
Format: Artikel
Sprache:eng
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Chemical Sciences
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Zusammenfassung:Abstract Two complementary Pd-catalyzed protocols enabling the γ-selective intermolecular allylic amination of but-3-enoic acid derivatives are reported. These transformations can be successfully achieved via either­ a direct Pd(II)-catalyzed protocol or by way of a one-pot Pd(II)/Pd(0)-catalyzed sequence, depending on the nature of the nitrogen nucleophile used.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0035-1562453