Endothelial precursor cell-based therapy to target the pathologic angiogenesis and compensate tumor hypoxia

Highlights • A model of tumor homing-cell based targeting of pathologic angiogenesis. • Defined endothelial precursor cells selectively seeking into the tumor vessels. • Potential cell therapy normalizing tumor angiogenesis by endothelial precursor cells. • Tumor microenvironment modification by fun...

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Veröffentlicht in:Cancer letters 2016-01, Vol.370 (2), p.345-357
Hauptverfasser: Collet, Guillaume, Szade, Krzysztof, Nowak, Witold, Klimkiewicz, Krzysztof, El Hafny-Rahbi, Bouchra, Szczepanek, Karol, Sugiyama, Daisuke, Weglarczyk, Kazimierz, Foucault-Collet, Alexandra, Guichard, Alan, Mazan, Andrzej, Nadim, Mahdi, Fasani, Fabienne, Lamerant-Fayel, Nathalie, Grillon, Catherine, Petoud, Stéphane, Beloeil, Jean-Claude, Jozkowicz, Alicja, Dulak, Jozef, Kieda, Claudine
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Sprache:eng
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Zusammenfassung:Highlights • A model of tumor homing-cell based targeting of pathologic angiogenesis. • Defined endothelial precursor cells selectively seeking into the tumor vessels. • Potential cell therapy normalizing tumor angiogenesis by endothelial precursor cells. • Tumor microenvironment modification by functional angiogenesis/vasculogenesis. • Endothelial precursor cells as carriers of therapeutic agents to tumor.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2015.11.008