From Enynyl Esters to Functionalized Polycyclic Derivatives via Cycloisomerization and Post-Functionalization

From Enynyl Esters to Functionalized Polycyclic Derivatives via Cycloisomerization and Post-Functionalization

Abstract The post-functionalization of ketone products originating from the PtCl 2 -catalyzed cycloisomerization of enynyl esters is described. Post-functionalization is accomplished via diastereoselective alkylation, regioselective cyclopropane opening and regioselective Baeyer–Villiger and Beckman...

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Veröffentlicht in:Synthesis (Stuttgart) 2016-10, Vol.48 (19), p.3199-3206
Hauptverfasser: Guelen, Simon, Blazejak, Max, Mouriès-Mansuy, Virginie, Fensterbank, Louis
Format: Artikel
Sprache:eng
Schlagworte:
Chemical Sciences
Organic chemistry
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Zusammenfassung:Abstract The post-functionalization of ketone products originating from the PtCl 2 -catalyzed cycloisomerization of enynyl esters is described. Post-functionalization is accomplished via diastereoselective alkylation, regioselective cyclopropane opening and regioselective Baeyer–Villiger and Beckmann rearrangements to provide functionalized polycycles.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0035-1561488