Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties
A water‐soluble template‐assembled synthetic G‐quartet (TASQ) based on the use of a macrocyclodecapeptide scaffold was designed to display stable intramolecular folds alone in solution. The preformation of the guanine quartet, demonstrated by NMR and CD investigations, results in enhanced peroxidase...
Gespeichert in:
| Veröffentlicht in: | Chemistry : a European journal 2016-01, Vol.22 (5), p.1760-1767 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1767 |
|---|---|
| container_issue | 5 |
| container_start_page | 1760 |
| container_title | Chemistry : a European journal |
| container_volume | 22 |
| creator | Flack, Theodore Constantin, Thibaut Penasse, Sylvain Dejeu, Jérôme Gennaro, Béatrice Jourdan, Muriel Laguerre, Aurélien Pirrotta, Marc Monchaud, David Spinelli, Nicolas Defrancq, Eric |
| description | A water‐soluble template‐assembled synthetic G‐quartet (TASQ) based on the use of a macrocyclodecapeptide scaffold was designed to display stable intramolecular folds alone in solution. The preformation of the guanine quartet, demonstrated by NMR and CD investigations, results in enhanced peroxidase‐type biocatalytic activities and improved quadruplex‐interacting properties. Comparison of its DNAzyme‐boosting properties with the ones of previously published TASQ revealed that, nowadays, it is the best DNAzyme‐boosting agent.
Significance of preformation: A water‐soluble template‐assembled synthetic G‐quartet (TASQ) has been prepared. It allows the formation of a stable and isolated G‐quartet in solution resulting in enhanced peroxidase‐type biocatalytic activities and improved quadruplex‐interacting properties. |
| doi_str_mv | 10.1002/chem.201504572 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_01400347v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3926031131</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6832-128aa7dceb102d600cb1b30e498ecc3ed4d5e175efd72fa27931ee38713ef0213</originalsourceid><addsrcrecordid>eNqF0UGP0zAQBWALgdiycOWIKnGBQ8qMHdvxcSndFiiwK0A9Wm4yUb2kSbAToP-eVFkqxIE9eWR986TRY-wpwgwB-Kt8R_sZB5SQSs3vsQlKjonQSt5nEzCpTpQU5ow9ivEGAIwS4iE740plRnExYZdXgcqmKqiYfj7U3Y46n0-XyXXvQkddnL7xsa3cYbqod67OB_XaN76OrQ_DfBWalkLnKT5mD0pXRXpy-56zr5eLL_NVsv60fDu_WCe5ygRPkGfO6SKnLQIvFEC-xa0ASk1GeS6oSAtJqCWVheal49oIJBKZRkElcBTn7OWYu3OVbYPfu3CwjfN2dbG2xz_AFECk-sfRvhhtG5rvPcXO7n3MqapcTU0fLWYAqRHCyLupVmAQpRQDff4PvWn6UA9HWzSgeYZDG_9VWmYIiDwd1GxUeWhiHIo4nYRgj_XaY732VO-w8Ow2tt_uqTjxP30OwIzgp6_ocEecna8WH_4OT8ZdHzv6ddp14ZtVWmhpNx-XNnuXvlfLzbXdiN_UWb0W</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1758101124</pqid></control><display><type>article</type><title>Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Flack, Theodore ; Constantin, Thibaut ; Penasse, Sylvain ; Dejeu, Jérôme ; Gennaro, Béatrice ; Jourdan, Muriel ; Laguerre, Aurélien ; Pirrotta, Marc ; Monchaud, David ; Spinelli, Nicolas ; Defrancq, Eric</creator><creatorcontrib>Flack, Theodore ; Constantin, Thibaut ; Penasse, Sylvain ; Dejeu, Jérôme ; Gennaro, Béatrice ; Jourdan, Muriel ; Laguerre, Aurélien ; Pirrotta, Marc ; Monchaud, David ; Spinelli, Nicolas ; Defrancq, Eric</creatorcontrib><description>A water‐soluble template‐assembled synthetic G‐quartet (TASQ) based on the use of a macrocyclodecapeptide scaffold was designed to display stable intramolecular folds alone in solution. The preformation of the guanine quartet, demonstrated by NMR and CD investigations, results in enhanced peroxidase‐type biocatalytic activities and improved quadruplex‐interacting properties. Comparison of its DNAzyme‐boosting properties with the ones of previously published TASQ revealed that, nowadays, it is the best DNAzyme‐boosting agent.
Significance of preformation: A water‐soluble template‐assembled synthetic G‐quartet (TASQ) has been prepared. It allows the formation of a stable and isolated G‐quartet in solution resulting in enhanced peroxidase‐type biocatalytic activities and improved quadruplex‐interacting properties.</description><identifier>ISSN: 0947-6539</identifier><identifier>EISSN: 1521-3765</identifier><identifier>DOI: 10.1002/chem.201504572</identifier><identifier>PMID: 26689623</identifier><identifier>CODEN: CEUJED</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Biocatalysis ; Cadmium ; Chemical Sciences ; Chemistry ; cyclodecapeptide ; DNA, Catalytic - chemistry ; DNA, Catalytic - metabolism ; DNAzyme ; Formations ; G-Quadruplexes ; G-quartets ; Guanine ; Guanines ; Models, Molecular ; NMR ; Nuclear magnetic resonance ; Nucleic Acid Conformation ; Peroxidase ; Scaffolds ; Solutions - chemistry ; supramolecular chemistry ; Water - chemistry</subject><ispartof>Chemistry : a European journal, 2016-01, Vol.22 (5), p.1760-1767</ispartof><rights>2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6832-128aa7dceb102d600cb1b30e498ecc3ed4d5e175efd72fa27931ee38713ef0213</citedby><cites>FETCH-LOGICAL-c6832-128aa7dceb102d600cb1b30e498ecc3ed4d5e175efd72fa27931ee38713ef0213</cites><orcidid>0000-0002-6857-011X ; 0000-0002-3056-9295 ; 0000-0002-3911-6241 ; 0000-0002-2434-2959</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fchem.201504572$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fchem.201504572$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26689623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://u-bourgogne.hal.science/hal-01400347$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Flack, Theodore</creatorcontrib><creatorcontrib>Constantin, Thibaut</creatorcontrib><creatorcontrib>Penasse, Sylvain</creatorcontrib><creatorcontrib>Dejeu, Jérôme</creatorcontrib><creatorcontrib>Gennaro, Béatrice</creatorcontrib><creatorcontrib>Jourdan, Muriel</creatorcontrib><creatorcontrib>Laguerre, Aurélien</creatorcontrib><creatorcontrib>Pirrotta, Marc</creatorcontrib><creatorcontrib>Monchaud, David</creatorcontrib><creatorcontrib>Spinelli, Nicolas</creatorcontrib><creatorcontrib>Defrancq, Eric</creatorcontrib><title>Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties</title><title>Chemistry : a European journal</title><addtitle>Chem. Eur. J</addtitle><description>A water‐soluble template‐assembled synthetic G‐quartet (TASQ) based on the use of a macrocyclodecapeptide scaffold was designed to display stable intramolecular folds alone in solution. The preformation of the guanine quartet, demonstrated by NMR and CD investigations, results in enhanced peroxidase‐type biocatalytic activities and improved quadruplex‐interacting properties. Comparison of its DNAzyme‐boosting properties with the ones of previously published TASQ revealed that, nowadays, it is the best DNAzyme‐boosting agent.
Significance of preformation: A water‐soluble template‐assembled synthetic G‐quartet (TASQ) has been prepared. It allows the formation of a stable and isolated G‐quartet in solution resulting in enhanced peroxidase‐type biocatalytic activities and improved quadruplex‐interacting properties.</description><subject>Biocatalysis</subject><subject>Cadmium</subject><subject>Chemical Sciences</subject><subject>Chemistry</subject><subject>cyclodecapeptide</subject><subject>DNA, Catalytic - chemistry</subject><subject>DNA, Catalytic - metabolism</subject><subject>DNAzyme</subject><subject>Formations</subject><subject>G-Quadruplexes</subject><subject>G-quartets</subject><subject>Guanine</subject><subject>Guanines</subject><subject>Models, Molecular</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Nucleic Acid Conformation</subject><subject>Peroxidase</subject><subject>Scaffolds</subject><subject>Solutions - chemistry</subject><subject>supramolecular chemistry</subject><subject>Water - chemistry</subject><issn>0947-6539</issn><issn>1521-3765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0UGP0zAQBWALgdiycOWIKnGBQ8qMHdvxcSndFiiwK0A9Wm4yUb2kSbAToP-eVFkqxIE9eWR986TRY-wpwgwB-Kt8R_sZB5SQSs3vsQlKjonQSt5nEzCpTpQU5ow9ivEGAIwS4iE740plRnExYZdXgcqmKqiYfj7U3Y46n0-XyXXvQkddnL7xsa3cYbqod67OB_XaN76OrQ_DfBWalkLnKT5mD0pXRXpy-56zr5eLL_NVsv60fDu_WCe5ygRPkGfO6SKnLQIvFEC-xa0ASk1GeS6oSAtJqCWVheal49oIJBKZRkElcBTn7OWYu3OVbYPfu3CwjfN2dbG2xz_AFECk-sfRvhhtG5rvPcXO7n3MqapcTU0fLWYAqRHCyLupVmAQpRQDff4PvWn6UA9HWzSgeYZDG_9VWmYIiDwd1GxUeWhiHIo4nYRgj_XaY732VO-w8Ow2tt_uqTjxP30OwIzgp6_ocEecna8WH_4OT8ZdHzv6ddp14ZtVWmhpNx-XNnuXvlfLzbXdiN_UWb0W</recordid><startdate>20160126</startdate><enddate>20160126</enddate><creator>Flack, Theodore</creator><creator>Constantin, Thibaut</creator><creator>Penasse, Sylvain</creator><creator>Dejeu, Jérôme</creator><creator>Gennaro, Béatrice</creator><creator>Jourdan, Muriel</creator><creator>Laguerre, Aurélien</creator><creator>Pirrotta, Marc</creator><creator>Monchaud, David</creator><creator>Spinelli, Nicolas</creator><creator>Defrancq, Eric</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><general>Wiley-VCH Verlag</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>K9.</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-6857-011X</orcidid><orcidid>https://orcid.org/0000-0002-3056-9295</orcidid><orcidid>https://orcid.org/0000-0002-3911-6241</orcidid><orcidid>https://orcid.org/0000-0002-2434-2959</orcidid></search><sort><creationdate>20160126</creationdate><title>Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties</title><author>Flack, Theodore ; Constantin, Thibaut ; Penasse, Sylvain ; Dejeu, Jérôme ; Gennaro, Béatrice ; Jourdan, Muriel ; Laguerre, Aurélien ; Pirrotta, Marc ; Monchaud, David ; Spinelli, Nicolas ; Defrancq, Eric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6832-128aa7dceb102d600cb1b30e498ecc3ed4d5e175efd72fa27931ee38713ef0213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biocatalysis</topic><topic>Cadmium</topic><topic>Chemical Sciences</topic><topic>Chemistry</topic><topic>cyclodecapeptide</topic><topic>DNA, Catalytic - chemistry</topic><topic>DNA, Catalytic - metabolism</topic><topic>DNAzyme</topic><topic>Formations</topic><topic>G-Quadruplexes</topic><topic>G-quartets</topic><topic>Guanine</topic><topic>Guanines</topic><topic>Models, Molecular</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Nucleic Acid Conformation</topic><topic>Peroxidase</topic><topic>Scaffolds</topic><topic>Solutions - chemistry</topic><topic>supramolecular chemistry</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flack, Theodore</creatorcontrib><creatorcontrib>Constantin, Thibaut</creatorcontrib><creatorcontrib>Penasse, Sylvain</creatorcontrib><creatorcontrib>Dejeu, Jérôme</creatorcontrib><creatorcontrib>Gennaro, Béatrice</creatorcontrib><creatorcontrib>Jourdan, Muriel</creatorcontrib><creatorcontrib>Laguerre, Aurélien</creatorcontrib><creatorcontrib>Pirrotta, Marc</creatorcontrib><creatorcontrib>Monchaud, David</creatorcontrib><creatorcontrib>Spinelli, Nicolas</creatorcontrib><creatorcontrib>Defrancq, Eric</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Chemistry : a European journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Flack, Theodore</au><au>Constantin, Thibaut</au><au>Penasse, Sylvain</au><au>Dejeu, Jérôme</au><au>Gennaro, Béatrice</au><au>Jourdan, Muriel</au><au>Laguerre, Aurélien</au><au>Pirrotta, Marc</au><au>Monchaud, David</au><au>Spinelli, Nicolas</au><au>Defrancq, Eric</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties</atitle><jtitle>Chemistry : a European journal</jtitle><addtitle>Chem. Eur. J</addtitle><date>2016-01-26</date><risdate>2016</risdate><volume>22</volume><issue>5</issue><spage>1760</spage><epage>1767</epage><pages>1760-1767</pages><issn>0947-6539</issn><eissn>1521-3765</eissn><coden>CEUJED</coden><abstract>A water‐soluble template‐assembled synthetic G‐quartet (TASQ) based on the use of a macrocyclodecapeptide scaffold was designed to display stable intramolecular folds alone in solution. The preformation of the guanine quartet, demonstrated by NMR and CD investigations, results in enhanced peroxidase‐type biocatalytic activities and improved quadruplex‐interacting properties. Comparison of its DNAzyme‐boosting properties with the ones of previously published TASQ revealed that, nowadays, it is the best DNAzyme‐boosting agent.
Significance of preformation: A water‐soluble template‐assembled synthetic G‐quartet (TASQ) has been prepared. It allows the formation of a stable and isolated G‐quartet in solution resulting in enhanced peroxidase‐type biocatalytic activities and improved quadruplex‐interacting properties.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>26689623</pmid><doi>10.1002/chem.201504572</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6857-011X</orcidid><orcidid>https://orcid.org/0000-0002-3056-9295</orcidid><orcidid>https://orcid.org/0000-0002-3911-6241</orcidid><orcidid>https://orcid.org/0000-0002-2434-2959</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0947-6539 |
| ispartof | Chemistry : a European journal, 2016-01, Vol.22 (5), p.1760-1767 |
| issn | 0947-6539 1521-3765 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_01400347v1 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Biocatalysis Cadmium Chemical Sciences Chemistry cyclodecapeptide DNA, Catalytic - chemistry DNA, Catalytic - metabolism DNAzyme Formations G-Quadruplexes G-quartets Guanine Guanines Models, Molecular NMR Nuclear magnetic resonance Nucleic Acid Conformation Peroxidase Scaffolds Solutions - chemistry supramolecular chemistry Water - chemistry |
| title | Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T03%3A11%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prefolded%20Synthetic%20G-Quartets%20Display%20Enhanced%20Bioinspired%20Properties&rft.jtitle=Chemistry%20:%20a%20European%20journal&rft.au=Flack,%20Theodore&rft.date=2016-01-26&rft.volume=22&rft.issue=5&rft.spage=1760&rft.epage=1767&rft.pages=1760-1767&rft.issn=0947-6539&rft.eissn=1521-3765&rft.coden=CEUJED&rft_id=info:doi/10.1002/chem.201504572&rft_dat=%3Cproquest_hal_p%3E3926031131%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1758101124&rft_id=info:pmid/26689623&rfr_iscdi=true |