Synthesis and Structural Characterization of 2:1 [[alpha]/Aza]-oligomers

Synthesis and Structural Characterization of 2:1 [[alpha]/Aza]-oligomers

The design of a new [beta]-turn inducer is correlated to the discovery of new foldamers. In this paper, we report the liquid phase synthesis of 2:1 [[alpha]/aza]-oligomers using a convergent Boc strategy. The NMR, FTIR, restrained molecular dynamics and X-ray diffraction analyses show that 2:1 [[alp...

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Veröffentlicht in:European journal of organic chemistry 2014-12, Vol.2014 (34), p.7643-7648
Hauptverfasser: Zhou, Zhou, Deng, Cheng, Abbas, Cécile, Didierjean, Claude, Averlant-Petit, Marie-Christine, Bodiguel, Jacques, Vanderesse, Régis, Jamart-Gregoire, Brigitte
Format: Artikel
Sprache:eng
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Chemical Sciences
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Zusammenfassung:The design of a new [beta]-turn inducer is correlated to the discovery of new foldamers. In this paper, we report the liquid phase synthesis of 2:1 [[alpha]/aza]-oligomers using a convergent Boc strategy. The NMR, FTIR, restrained molecular dynamics and X-ray diffraction analyses show that 2:1 [[alpha]/aza]-oligomers adopt a C=O(i)···H-N(i + 2) hydrogen-bonded helical conformation.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201402628