Retrotransposons jump into alternative-splicing regulation via a long noncoding RNA

Retrotransposons jump into alternative-splicing regulation via a long noncoding RNA

A conserved long noncoding RNA expressed at the 5S rDNA ribosomal locus has acquired a novel function in alternative-splicing regulation in primates, owing to the insertion of a mobile Alu element. This discovery opens new perspectives regarding the roles of transposable elements in expanding the hu...

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Veröffentlicht in:Nature structural & molecular biology 2016-11, Vol.23 (11), p.952-954
1. Verfasser: Luco, Reini F
Format: Artikel
Sprache:eng
Schlagworte:
631/337/1645/1792
631/337/384/2568
Alternative Splicing
Biochemistry
Biological Microscopy
Biotechnology
Deoxyribonucleic acid
DNA
Gene expression
Genetics
Life Sciences
Membrane Biology
news-and-views
Protein Structure
Retroelements
Retrotransposons
Ribonucleic acid
RNA
RNA, Long Noncoding - genetics
Transposons
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Beschreibung
Zusammenfassung:A conserved long noncoding RNA expressed at the 5S rDNA ribosomal locus has acquired a novel function in alternative-splicing regulation in primates, owing to the insertion of a mobile Alu element. This discovery opens new perspectives regarding the roles of transposable elements in expanding the human transcriptome and may be applied as a biotechnology tool to drive gene-specific changes in alternative splicing.
ISSN:1545-9993
1545-9985
DOI:10.1038/nsmb.3318