In vitro expansion of U87-MG human glioblastoma cells under hypoxic conditions affects glucose metabolism and subsequent in vivo growth

In vitro expansion of U87-MG human glioblastoma cells under hypoxic conditions affects glucose metabolism and subsequent in vivo growth

Hypoxia is a characteristic feature of solid tumors leading to the over expression of hypoxia-inducible factor (HIF)-1α protein and therefore to a specific cellular behavior. However, even though the oxygen tension in tumors is low (

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Bibliographische Detailangaben
Veröffentlicht in:Tumor biology 2015-09, Vol.36 (10), p.7699-7710
Hauptverfasser: Lemaire, L., Franconi, F., Siegler, B., Legendre, C., Garcion, E.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biomedical and Life Sciences
Biomedicine
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
Cancer Research
Cell Line, Tumor
Cellular biology
Female
Glioblastoma - metabolism
Glioblastoma - pathology
Glucose - metabolism
Humans
Hypoxia
Hypoxia - metabolism
Hypoxia - pathology
Life Sciences
Metabolism
Mice
Mice, Nude
Oxygen - metabolism
Research Article
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Beschreibung
Zusammenfassung:Hypoxia is a characteristic feature of solid tumors leading to the over expression of hypoxia-inducible factor (HIF)-1α protein and therefore to a specific cellular behavior. However, even though the oxygen tension in tumors is low (
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-015-3458-3