Asymmetric reduction of acetophenone over heterogeneous oxazaborolidine catalysts
The reduction of acetophenone over the heterogeneous catalyst NiB 2–0.1(oxazaborolidine) 0.1 by borane in THF at 273 K is quicker than in homogeneous phase. The catalyst presented high enantioselectivity (ee ≥90%) at low molar ratio provided the ketone was added very slowly to the catalyst and boran...
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| Veröffentlicht in: | Tetrahedron: asymmetry 2000-06, Vol.11 (11), p.2263-2266 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | The reduction of acetophenone over the heterogeneous catalyst NiB
2–0.1(oxazaborolidine)
0.1 by borane in THF at 273 K is quicker than in homogeneous phase. The catalyst presented high enantioselectivity (ee ≥90%) at low molar ratio provided the ketone was added very slowly to the catalyst and borane complex. |
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| ISSN: | 0957-4166 1362-511X 0957-4166 |
| DOI: | 10.1016/S0957-4166(00)00191-9 |