Role of the tumor microenvironment in regulating apoptosis and cancer progression

Highlights • The impairment of cell death represents the main factor of cancer outbreak, as well as the resistance to anti-cancer agents. • Tumor microenvironment has a critical importance in immune escape, therefore promoting tumor progression and metastasis. • Inflammatory responses modulate the t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2016-08, Vol.378 (2), p.150-159
Hauptverfasser:	Yaacoub, Katherine, Pedeux, Remy, Tarte, Karin, Guillaudeux, Thierry
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Cancer Cancer therapies Cell Proliferation Disease Progression Hematology, Oncology and Palliative Medicine Humans Immune escape Inflammation Inflammation Mediators - metabolism Kinases Life Sciences Microenvironment Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology Receptors, Immunologic - metabolism Resistance Signal Transduction Tumor Escape Tumor Microenvironment Tumor necrosis factor-TNF
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • The impairment of cell death represents the main factor of cancer outbreak, as well as the resistance to anti-cancer agents. • Tumor microenvironment has a critical importance in immune escape, therefore promoting tumor progression and metastasis. • Inflammatory responses modulate the tumor microenvironment and play a decisive role in tumor development. • Microenvironment-targeted therapies might be a real gain to fight cancer.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.05.012