Multifunctional squalene-based prodrug nanoparticles for targeted cancer therapy

Multifunctional squalene-based prodrug nanoparticles for targeted cancer therapy

Fluorescent and biotinylated squalene-gemcitabine prodrug nanoparticles exhibiting high drug payloads have been prepared and successfully used to target different cancer cell lines, resulting in increased cell uptake and improved anticancer efficiency, which represents the first targeted system deri...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2014-01, Vol.50 (40), p.5336-5338
Hauptverfasser: Bui, Duc Trung, Nicolas, Julien, Maksimenko, Andrei, Desmaële, Didier, Couvreur, Patrick
Format: Artikel
Sprache:eng
Schlagworte:
Antimetabolites, Antineoplastic - therapeutic use
Chemical Sciences
Deoxycytidine - analogs & derivatives
Deoxycytidine - therapeutic use
Drug Delivery Systems
Humans
Life Sciences
Nanomedicine
Nanoparticles - chemistry
Neoplasms - diagnosis
Neoplasms - drug therapy
Neoplasms - metabolism
Prodrugs - therapeutic use
Squalene - chemistry
Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:Fluorescent and biotinylated squalene-gemcitabine prodrug nanoparticles exhibiting high drug payloads have been prepared and successfully used to target different cancer cell lines, resulting in increased cell uptake and improved anticancer efficiency, which represents the first targeted system derived from the squalenoylation approach.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc47427e