Quality Control Initiative on the Evaluation of the Dysmegakaryopoiesis in Myeloid Neoplasms: Difficulties in the Assessment of Dysplasia
Highlights • The presence of micromegakaryocytes correlates strongly with myeloid neoplasia • Micromegakaryocytes can be identified reliably • Multinucleated megakaryocytes are not specific for myeloid neoplasia • Cytoplasmic dysplasia is not useful in recognising MDS • ‘Possibly dysplastic’ cells s...
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Veröffentlicht in: | Leukemia research 2016-06, Vol.45, p.75-81 |
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container_title | Leukemia research |
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creator | Goasguen, Jean E Bennett, John M Bain, Barbara J Brunning, Richard D Vallespí, Maria-Teresa Tomonaga, Masao Zini, Gina Renault, Alain |
description | Highlights • The presence of micromegakaryocytes correlates strongly with myeloid neoplasia • Micromegakaryocytes can be identified reliably • Multinucleated megakaryocytes are not specific for myeloid neoplasia • Cytoplasmic dysplasia is not useful in recognising MDS • ‘Possibly dysplastic’ cells should be excluded from counts in suspected MDS |
doi_str_mv | 10.1016/j.leukres.2016.04.009 |
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subjects | Cancer Cell Shape Cell Size Dysmegakaryocytopoiesis Dysmegakaryopoiesis Dysmyelopoiesis Dysplastic features Hematologic Neoplasms - pathology Hematology Hematology, Oncology and Palliative Medicine Human health and pathology Humans Life Sciences Megakaryocyte Progenitor Cells Megakaryocytes Megakaryocytes - pathology Myelodysplastic syndrome Myelodysplastic Syndromes - diagnosis Myeloproliferative Disorders - diagnosis Quality Control Tissues and Organs |
title | Quality Control Initiative on the Evaluation of the Dysmegakaryopoiesis in Myeloid Neoplasms: Difficulties in the Assessment of Dysplasia |
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