Layered double hydroxide and sulindac coiled and scrolled nanoassemblies for storage and drug release

Sulindac, a non-steroidal anti-inflammatory of the indene acetic acid class, was immobilized inside layered double hydroxide Mg 2 Al and Zn 2 Al (LDH) nanovessels through a one pot reaction. LDH-drug materials were characterized by chemical elemental analysis, X-ray diffraction (XRD) (one dimensional electron distribution along the c -stacking axis, pair distribution function analysis), scanning and transmission electron microscopies, mass coupled thermal analyses, vibrational infrared and Raman spectroscopies, and solid state 13 C NMR. Density Functional Theory (DFT) calculations were performed for sulindac (protonated and deprotonated forms) with the aim to assign the LDH-drug spectroscopic results. All converge towards a spatial organization of interleaved sulindac molecules close to that reported for the pristine polymorph II crystal structure. Of relevance for human treatment because of its biocompatibility and non-immunogenic effect, in vitro sulindac release experiments were performed in a phosphate buffer mimicking biological fluids and release profiles were refined using kinetic models. Systems comprising anti-inflammatory sulindac intercalated into biocompatible layered double hydroxides nanovehicles were isolated through one pot synthetic method and showed high crystallinity and curled or scrolled particles.