Copper-catalyzed direct C-H fluoroalkenylation of heteroarenes

Copper-catalyzed direct C-H fluoroalkenylation of heteroarenes

Copper-catalyzed direct C-H fluoroalkenylation of heterocycles using various gem-bromofluoroalkenes as electrophiles is reported. This efficient method offers step-economical, low-cost and stereocontrolled access to relevant heteroarylated monofluoroalkenes. The synthesis of fluorinated analogues of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic & biomolecular chemistry 2016-01, Vol.14 (1), p.353-357
Hauptverfasser: Rousée, Kevin, Schneider, Cédric, Bouillon, Jean-Philippe, Levacher, Vincent, Hoarau, Christophe, Couve-Bonnaire, Samuel, Pannecoucke, Xavier
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemistry
Analytical chemistry
Catalysis
Chemical Sciences
Cheminformatics
Copper - chemistry
Heterocyclic Compounds - chemistry
Hydrocarbons, Fluorinated - chemical synthesis
Hydrocarbons, Fluorinated - chemistry
Medicinal Chemistry
Molecular Structure
or physical chemistry
Organic chemistry
Theoretical and
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Copper-catalyzed direct C-H fluoroalkenylation of heterocycles using various gem-bromofluoroalkenes as electrophiles is reported. This efficient method offers step-economical, low-cost and stereocontrolled access to relevant heteroarylated monofluoroalkenes. The synthesis of fluorinated analogues of biomolecules and therapeutic agents for the treatment of Duchenne muscular dystrophy as application is reported.
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob02213d