Very bright europium complexes that stain cellular mitochondria

The synthesis, structure and photophysical properties of a series of highly emissive europium complexes is reported. Certain complexes enter mammalian cells by macropinocytosis and stain the mitochondria selectively, allowing observation of the Eu emission in cellulo by time-gated spectral imaging.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (16), p.1600-1602
Hauptverfasser:	Walton, James W, Bourdolle, Adrien, Butler, Stephen J, Soulie, Marine, Delbianco, Martina, McMahon, Brian K, Pal, Robert, Puschmann, Horst, Zwier, Jurriaan M, Lamarque, Laurent, Maury, Olivier, Andraud, Chantal, Parker, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Amiloride - pharmacology Androstadienes - pharmacology Animals Catalysis Chemical Sciences Europium - analysis Europium - chemistry Inorganic chemistry Material chemistry Mice Mitochondria - chemistry Mitochondria - drug effects Mitochondria - metabolism Models, Molecular Molecular Structure NIH 3T3 Cells Organic chemistry Organometallic Compounds - analysis Organometallic Compounds - antagonists & inhibitors Organometallic Compounds - chemistry Temperature
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Beschreibung
Zusammenfassung:	The synthesis, structure and photophysical properties of a series of highly emissive europium complexes is reported. Certain complexes enter mammalian cells by macropinocytosis and stain the mitochondria selectively, allowing observation of the Eu emission in cellulo by time-gated spectral imaging.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c2cc35247h