A Phase 2 study of L‐asparaginase encapsulated in erythrocytes in elderly patients with Philadelphia chromosome negative acute lymphoblastic leukemia: The GRASPALL/GRAALL‐SA2‐2008 study

Purpose: The GRASPALL/GRAALL‐SA2‐2008 Phase II trial evaluated the safety and efficacy of L‐asparaginase encapsulated within erythrocytes (GRASPA®) in patients ≥ 55 years with Philadelphia chromosome‐negative acute lymphoblastic leukemia. Findings: Thirty patients received escalating doses of GRASPA...

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Veröffentlicht in:	American journal of hematology 2015-09, Vol.90 (9), p.811-818
Hauptverfasser:	Hunault‐Berger, Mathilde, Leguay, Thibaut, Huguet, Françoise, Leprêtre, Stéphane, Deconinck, Eric, Ojeda-Uribe, Mario, Bonmati, Caroline, Escoffre‐Barbe, Martine, Bories, Pierre, Himberlin, Chantal, Chevallier, Patrice, Rousselot, Philippe, Reman, Oumedaly, Boulland, Marie‐Laure, Lissandre, Severine, Turlure, Pascal, Bouscary, Didier, Sanhes, Laurence, Legrand, Ollivier, Lafage‐Pochitaloff, Marina, Béné, Marie C, Liens, David, Godfrin, Yann, Ifrah, Norbert, Dombret, Hervé
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anti-Bacterial Agents - therapeutic use Antifungal Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols Asparaginase - therapeutic use Asparagine - metabolism Drug Carriers Drug Compounding Erythrocytes - chemistry Erythrocytes - cytology Female Gram-Negative Bacterial Infections - complications Gram-Negative Bacterial Infections - drug therapy Gram-Negative Bacterial Infections - mortality Gram-Negative Bacterial Infections - pathology Gram-Positive Bacterial Infections - complications Gram-Positive Bacterial Infections - drug therapy Gram-Positive Bacterial Infections - mortality Gram-Positive Bacterial Infections - pathology Hematology Humans Leukemia Life Sciences Male Middle Aged Mycoses - complications Mycoses - drug therapy Mycoses - mortality Mycoses - pathology Philadelphia Chromosome Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Remission Induction Survival Analysis
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Zusammenfassung:	Purpose: The GRASPALL/GRAALL‐SA2‐2008 Phase II trial evaluated the safety and efficacy of L‐asparaginase encapsulated within erythrocytes (GRASPA®) in patients ≥ 55 years with Philadelphia chromosome‐negative acute lymphoblastic leukemia. Findings: Thirty patients received escalating doses of GRASPA® on Day 3 and 6 of induction Phases 1 and 2. The primary efficacy endpoint was asparagine depletion
ISSN:	0361-8609 1096-8652
DOI:	10.1002/ajh.24093