A convergent, modular access to α-chloro-trifluoromethyl derivatives and to 1,1-difluoroalkenes
An efficient protocol for the preparation of S-(1-chloro-2,2,2-trifluoroethyl)-O-ethyl xanthate is reported. This reagent serves as a versatile precursor of highly functionalized gem-difluoroalkenes through various inter- and intramolecular radical reactions and subsequent reduction with activated m...
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| Veröffentlicht in: | Tetrahedron 2015-09, Vol.71 (39), p.7144-7153 |
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| container_end_page | 7153 |
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| container_issue | 39 |
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| container_title | Tetrahedron |
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| creator | Salomon, Pierre Kosnik, Wioletta Zard, Samir Z. |
| description | An efficient protocol for the preparation of S-(1-chloro-2,2,2-trifluoroethyl)-O-ethyl xanthate is reported. This reagent serves as a versatile precursor of highly functionalized gem-difluoroalkenes through various inter- and intramolecular radical reactions and subsequent reduction with activated magnesium metal.
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| doi_str_mv | 10.1016/j.tet.2014.11.021 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Tetrahedron, 2015-09, Vol.71 (39), p.7144-7153 |
| issn | 0040-4020 1464-5416 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_01224738v1 |
| source | Access via ScienceDirect (Elsevier) |
| subjects | Chemical Sciences Fluorine Organic chemistry Radical addition Xanthates |
| title | A convergent, modular access to α-chloro-trifluoromethyl derivatives and to 1,1-difluoroalkenes |
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