A convergent, modular access to α-chloro-trifluoromethyl derivatives and to 1,1-difluoroalkenes

A convergent, modular access to α-chloro-trifluoromethyl derivatives and to 1,1-difluoroalkenes

An efficient protocol for the preparation of S-(1-chloro-2,2,2-trifluoroethyl)-O-ethyl xanthate is reported. This reagent serves as a versatile precursor of highly functionalized gem-difluoroalkenes through various inter- and intramolecular radical reactions and subsequent reduction with activated m...

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Veröffentlicht in:Tetrahedron 2015-09, Vol.71 (39), p.7144-7153
Hauptverfasser: Salomon, Pierre, Kosnik, Wioletta, Zard, Samir Z.
Format: Artikel
Sprache:eng
Schlagworte:
Chemical Sciences
Fluorine
Organic chemistry
Radical addition
Xanthates
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Zusammenfassung:An efficient protocol for the preparation of S-(1-chloro-2,2,2-trifluoroethyl)-O-ethyl xanthate is reported. This reagent serves as a versatile precursor of highly functionalized gem-difluoroalkenes through various inter- and intramolecular radical reactions and subsequent reduction with activated magnesium metal. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2014.11.021