Brain metabolic abnormalities during gait with freezing in Parkinson’s disease

Highlights • Freezing of gait was related to hypometabolism of premotor area during actual gait. • Freezers presented a hypermetabolism of the posterior parietal cortex during gait. • Parietofrontal network was involved in freezing phenomenon. • Basal ganglia overactivation during gait was observed...

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Veröffentlicht in:	Neuroscience 2015-10, Vol.307, p.281-301
Hauptverfasser:	Tard, C, Delval, A, Devos, D, Lopes, R, Lenfant, P, Dujardin, K, Hossein-Foucher, C, Semah, F, Duhamel, A, Defebvre, L, Le Jeune, F, Moreau, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged associative somatosensory cortex Brain - diagnostic imaging Brain - metabolism Cluster Analysis executive-attention network Female Fluorodeoxyglucose F18 Gait Disorders, Neurologic - etiology Human health and pathology Humans Life Sciences Male Middle Aged Neurology Neuropsychological Tests Parkinson Disease - diagnostic imaging Parkinson Disease - pathology PET Positron-Emission Tomography premotor cortex Severity of Illness Index Statistics, Nonparametric temporopolar area
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Beschreibung
Zusammenfassung:	Highlights • Freezing of gait was related to hypometabolism of premotor area during actual gait. • Freezers presented a hypermetabolism of the posterior parietal cortex during gait. • Parietofrontal network was involved in freezing phenomenon. • Basal ganglia overactivation during gait was observed in freezers patients. • The balance between external and internal signals may fail during freezing.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.08.063