Effect of serotonin transporter blockade on L-DOPA-induced dyskinesia in animal models of Parkinson’s disease
Highlights • The serotonergic system plays a key role in LID. • The SSRI citalopram is able to fully counteract LID in 6-OHDA-lesioned rats. • Citalopram also suppressed LID in MPTP-treated macaques but affected L-DOPA efficacy.
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| Veröffentlicht in: | Neuroscience 2015-07, Vol.298, p.389-396 |
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| container_title | Neuroscience |
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| creator | Fidalgo, C Ko, W.K.D Tronci, E Li, Q Stancampiano, R Chuan, Q Bezard, E Carta, M |
| description | Highlights • The serotonergic system plays a key role in LID. • The SSRI citalopram is able to fully counteract LID in 6-OHDA-lesioned rats. • Citalopram also suppressed LID in MPTP-treated macaques but affected L-DOPA efficacy. |
| doi_str_mv | 10.1016/j.neuroscience.2015.04.027 |
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All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c535t-6697c92cd4491ea7cb6e73304e0fc592a6f82e9d9c67f5b9a005dd764ee5837e3</citedby><cites>FETCH-LOGICAL-c535t-6697c92cd4491ea7cb6e73304e0fc592a6f82e9d9c67f5b9a005dd764ee5837e3</cites><orcidid>0000-0002-0410-4638</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0306452215003681$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25907446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01179330$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Fidalgo, C</creatorcontrib><creatorcontrib>Ko, W.K.D</creatorcontrib><creatorcontrib>Tronci, E</creatorcontrib><creatorcontrib>Li, Q</creatorcontrib><creatorcontrib>Stancampiano, R</creatorcontrib><creatorcontrib>Chuan, Q</creatorcontrib><creatorcontrib>Bezard, E</creatorcontrib><creatorcontrib>Carta, M</creatorcontrib><title>Effect of serotonin transporter blockade on L-DOPA-induced dyskinesia in animal models of Parkinson’s disease</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Highlights • The serotonergic system plays a key role in LID. • The SSRI citalopram is able to fully counteract LID in 6-OHDA-lesioned rats. • Citalopram also suppressed LID in MPTP-treated macaques but affected L-DOPA efficacy.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Antiparkinson Agents - adverse effects</subject><subject>citalopram</subject><subject>Citalopram - therapeutic use</subject><subject>Cognitive science</subject><subject>Disease Models, Animal</subject><subject>dopamine</subject><subject>dyskinesia</subject><subject>Dyskinesia, Drug-Induced - drug therapy</subject><subject>Dyskinesia, Drug-Induced - etiology</subject><subject>Dyskinesia, Drug-Induced - metabolism</subject><subject>Female</subject><subject>Levodopa - adverse effects</subject><subject>Life Sciences</subject><subject>Macaca</subject><subject>Macaca fascicularis</subject><subject>Male</subject><subject>MPTP Poisoning - chemically induced</subject><subject>MPTP Poisoning - drug therapy</subject><subject>Neurology</subject><subject>Neuroscience</subject><subject>Oxidopamine - toxicity</subject><subject>Parkinson Disease - drug therapy</subject><subject>Parkinson Disease - etiology</subject><subject>Parkinson’s disease</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>serotonin</subject><subject>Serotonin Plasma Membrane Transport Proteins - metabolism</subject><subject>Serotonin Uptake Inhibitors - therapeutic use</subject><subject>Time Factors</subject><subject>Tyrosine 3-Monooxygenase - metabolism</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1uEzEUhUcIREPhFZDFChYz-N8zLJCitrRIkVoJWFuOfUc4mdjBnqmUHa_B6_EkeJS0QqzwxpJ97rn2-W5VvSG4IZjI95smwJRith6ChYZiIhrMG0zVk2pBWsVqJTh_Wi0ww7LmgtKz6kXOG1yW4Ox5dUZFhxXnclHFq74HO6LYowwpjjH4gMZkQt7HNEJC6yHarXGAYkCr-vL2bln74CYLDrlD3voA2RtUikzwOzOgXXQw5NnvzqRynWP4_fNXRs5nMBleVs96M2R4ddrPq2-frr5e3NSr2-vPF8tVbQUTYy1lp2xHreO8I2CUXUtQjGEOuLeio0b2LYXOdVaqXqw7U37mnJIcQLRMATuv3h19v5tB71N5WjroaLy-Wa70fIYJUV1xvCdF-_ao3af4Y4I86p3PFobBBIhT1kQx2jJOhSzSD0epLfnnBP2jN8F6hqM3-m84eoajMdcFTil-feozrXfgHksfaBTB5VFQEoR7D0mfbJxPBZJ20f9fn4__2NjBB2_NsIUD5E2cUijZa6Iz1Vh_mcdknhIiMGayJewPH4W9Sg</recordid><startdate>20150709</startdate><enddate>20150709</enddate><creator>Fidalgo, C</creator><creator>Ko, W.K.D</creator><creator>Tronci, E</creator><creator>Li, Q</creator><creator>Stancampiano, R</creator><creator>Chuan, Q</creator><creator>Bezard, E</creator><creator>Carta, M</creator><general>Elsevier Ltd</general><general>Elsevier - International Brain Research Organization</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-0410-4638</orcidid></search><sort><creationdate>20150709</creationdate><title>Effect of serotonin transporter blockade on L-DOPA-induced dyskinesia in animal models of Parkinson’s disease</title><author>Fidalgo, C ; 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| subjects | Analysis of Variance Animals Antiparkinson Agents - adverse effects citalopram Citalopram - therapeutic use Cognitive science Disease Models, Animal dopamine dyskinesia Dyskinesia, Drug-Induced - drug therapy Dyskinesia, Drug-Induced - etiology Dyskinesia, Drug-Induced - metabolism Female Levodopa - adverse effects Life Sciences Macaca Macaca fascicularis Male MPTP Poisoning - chemically induced MPTP Poisoning - drug therapy Neurology Neuroscience Oxidopamine - toxicity Parkinson Disease - drug therapy Parkinson Disease - etiology Parkinson’s disease Rats Rats, Sprague-Dawley serotonin Serotonin Plasma Membrane Transport Proteins - metabolism Serotonin Uptake Inhibitors - therapeutic use Time Factors Tyrosine 3-Monooxygenase - metabolism |
| title | Effect of serotonin transporter blockade on L-DOPA-induced dyskinesia in animal models of Parkinson’s disease |
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