Intrapallidal administration of 6-hydroxydopamine mimics in large part the electrophysiological and behavioral consequences of major dopamine depletion in the rat

Highlights ► Intrapallidal injection of 6-OHDA results in motor deficits. ► Intrapallidal injection of 6-OHDA increases burst activity in STN neurons. ► Intrapallidal injection of 6-OHDA increases irregular activity in SNr neurons.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2013-04, Vol.236, p.289-297
Hauptverfasser:	Abedi, P.M, Delaville, C, De Deurwaerdère, P, Benjelloun, W, Benazzouz, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Agents - administration & dosage Animals Biological and medical sciences Chromatography, High Pressure Liquid Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases dopamine Dopamine - metabolism electrophysiology globus pallidus Globus Pallidus - drug effects Globus Pallidus - metabolism Injections, Intraventricular Life Sciences Male Medical sciences Motor Activity - drug effects Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Neurons - metabolism Oxidopamine - administration & dosage Parkinson Disease - metabolism Parkinson’s disease Patch-Clamp Techniques Rats Rats, Sprague-Dawley substantia nigra pars reticulata subthalamic nucleus
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Zusammenfassung:	Highlights ► Intrapallidal injection of 6-OHDA results in motor deficits. ► Intrapallidal injection of 6-OHDA increases burst activity in STN neurons. ► Intrapallidal injection of 6-OHDA increases irregular activity in SNr neurons.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.01.043