An Efficient Synthesis of 3,3′-Bipiperidines Using an ROM/RCM Metathesis Sequence: Extension to Oxygenated Analogues

An Efficient Synthesis of 3,3′-Bipiperidines Using an ROM/RCM Metathesis Sequence: Extension to Oxygenated Analogues

Abstract A short and efficient diastereoselective synthesis of 3,3′-bipiperidine and 3,3′-bis(1,2,3,6-tetrahydropyridine) was accomplished using a tandem ring-opening metathesis/ring-closing metathesis (ROM/RCM) sequence as a key step. This strategy has been extended to the synthesis of the oxygenat...

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Veröffentlicht in:Synthesis (Stuttgart) 2014-12, Vol.46 (23), p.3268-3272
Hauptverfasser: Maougal, Esma, Dalençon, Sylvain, Pearson-Long, Morwenna S. M., Mathé-Allainmat, Monique, Lebreton, Jacques, Legoupy, Stéphanie
Format: Artikel
Sprache:eng
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Chemical Sciences
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Zusammenfassung:Abstract A short and efficient diastereoselective synthesis of 3,3′-bipiperidine and 3,3′-bis(1,2,3,6-tetrahydropyridine) was accomplished using a tandem ring-opening metathesis/ring-closing metathesis (ROM/RCM) sequence as a key step. This strategy has been extended to the synthesis of the oxygenated analogues.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0034-1378663