Role of corticosteroid binding globulin in emotional reactivity sex differences in mice

Highlights • Sex differences in emotional behavior were found in wild-type but not in Cbg k.o. mice. • Estradiol concentrations are responsible for the sex differences in wild-type mice. • CBG is required to attain optimal glucocorticoid concentrations after stress. • A complex interaction of CBG an...

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Veröffentlicht in:	Psychoneuroendocrinology 2014-12, Vol.50, p.252-263
Hauptverfasser:	Minni, A.M, de Medeiros, G.F, Helbling, J.C, Duittoz, A, Marissal-Arvy, N, Foury, A, De Smedt-Peyrusse, V, Pallet, V, Moisan, M.P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Animals Behavioral psychophysiology Biological and medical sciences Circadian Rhythm - physiology Corticosterone - blood Depression Disease Models, Animal Emotions - physiology Endocrinology & Metabolism Estrogens Female Fundamental and applied biological sciences. Psychology Glucocorticoid Hormones and behavior Hypothalamo-Hypophyseal System - metabolism Hypothalamo-Hypophyseal System - physiopathology Life Sciences Male Medical sciences Mice Mice, Knockout Miscellaneous Mood disorders Other Pituitary-Adrenal System - metabolism Pituitary-Adrenal System - physiopathology Psychiatry Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Sex Characteristics Sex difference Stress Stress, Psychological - metabolism Stress, Psychological - physiopathology Transcortin Transcortin - genetics Transcortin - metabolism
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Zusammenfassung:	Highlights • Sex differences in emotional behavior were found in wild-type but not in Cbg k.o. mice. • Estradiol concentrations are responsible for the sex differences in wild-type mice. • CBG is required to attain optimal glucocorticoid concentrations after stress. • A complex interaction of CBG and E2 on emotional reactivity is observed in females.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2014.07.029