Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol

Highlights • AOH induces autophagy, lamellar bodies and senescence in RAW264.7 macrophages. • DNA damage is suggested as a triggering signal. • The Sestrin2-AMPK-mTOR-S6K pathway is proposed to link DNA damage to autophagy.

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Bibliographische Detailangaben
Veröffentlicht in:	Toxicology (Amsterdam) 2014-12, Vol.326, p.119-129
Hauptverfasser:	Solhaug, A, Torgersen, M.L, Holme, J.A, Lagadic-Gossmann, D, Eriksen, G.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Alternariol AMP-Activated Protein Kinases - metabolism Animals Autophagy Autophagy - drug effects Cell Line Cellular Cellular Senescence - drug effects DNA Breaks, Double-Stranded Dose-Response Relationship, Drug Emergency Kinases Lactones - toxicity Lamellar bodies Lamellar structure Life Sciences Macrophages - drug effects Macrophages - metabolism Macrophages - ultrastructure Mice mTOR Mycotoxins Mycotoxins - toxicity Nuclear Proteins - metabolism Pathways Phosphorylation Ribosomal Protein S6 Kinases - metabolism Senescence Sestrin2 Signal Transduction - drug effects Stress, Physiological - drug effects Stresses Time Factors TOR Serine-Threonine Kinases - metabolism Tumor Suppressor Protein p53 - metabolism
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Beschreibung
Zusammenfassung:	Highlights • AOH induces autophagy, lamellar bodies and senescence in RAW264.7 macrophages. • DNA damage is suggested as a triggering signal. • The Sestrin2-AMPK-mTOR-S6K pathway is proposed to link DNA damage to autophagy.
ISSN:	0300-483X 1879-3185
DOI:	10.1016/j.tox.2014.10.009