Understanding carbon catabolite repression in Escherichia coli using quantitative models

Highlights • Carbon catabolite repression (CCR) has motivated important modeling efforts. • A simplified representation of diauxic growth is useful for comparing existing models. • Different models, based on different hypotheses, can quantitatively account for CCR. • Mechanistic models of CCR could...

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Veröffentlicht in:	Trends in microbiology (Regular ed.) 2015-02, Vol.23 (2), p.99-109
Hauptverfasser:	Kremling, A, Geiselmann, J, Ropers, D, de Jong, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomass Carbon - metabolism carbon catabolite repression Catabolite Repression - genetics Escherichia coli Escherichia coli - genetics Escherichia coli - growth & development Escherichia coli - metabolism Gene Expression Regulation, Bacterial Internal Medicine Life Sciences mathematical modeling Microbiology and Parasitology Models, Biological Quantitative Methods Signal Transduction - genetics systems biology
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Beschreibung
Zusammenfassung:	Highlights • Carbon catabolite repression (CCR) has motivated important modeling efforts. • A simplified representation of diauxic growth is useful for comparing existing models. • Different models, based on different hypotheses, can quantitatively account for CCR. • Mechanistic models of CCR could be improved by integrating global cell physiology.
ISSN:	0966-842X 1878-4380
DOI:	10.1016/j.tim.2014.11.002