Palladium-Catalyzed Hydrophosphonylation of Alkenes with Dialkyl H-Phosphonates

The palladium‐catalyzed hydrophosphonylation of alkenes with previously unreactive acyclic dialkyl H‐phosphonates has been developed. A catalyst system based on palladium/DavePhos or palladium/SPhos enables the transformation of various alkenes to phosphonates in moderate to good yields and with exc...

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Veröffentlicht in:	Advanced synthesis & catalysis 2014-08, Vol.356 (11-12), p.2703-2708
Hauptverfasser:	Candy, Mathieu, Rousseaux, Sophie A. L., San Román, Alberto Cirugeda, Szymczyk, Monika, Kafarski, Pawel, Leclerc, Eric, Vrancken, Emmanuel, Campagne, Jean-Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	acyclic dialkyl H-phosphonates Alkenes Catalysis Catalysts Chemical Sciences hydrophosphonylation Organic chemistry Palladium palladium catalysis Phosphonates regioselectivity Synthesis Transformations
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Beschreibung
Zusammenfassung:	The palladium‐catalyzed hydrophosphonylation of alkenes with previously unreactive acyclic dialkyl H‐phosphonates has been developed. A catalyst system based on palladium/DavePhos or palladium/SPhos enables the transformation of various alkenes to phosphonates in moderate to good yields and with excellent levels of regioselectivity. Hydrophosphonylations with internal, disubstituted and/or unactivated alkenes are also reported.
ISSN:	1615-4150 1615-4169
DOI:	10.1002/adsc.201400190