Targeting of Smoothened for therapeutic gain

Targeting of Smoothened for therapeutic gain

Highlights • Smo antagonists have potential for cancer therapy. • Positive modulators of Smo may also be therapeutics. • Models of canonical and noncanonical Hedgehog signaling modulation by Smo ligands are presented. • The three-dimensional structure of Smo provides ligand design perspectives....

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Veröffentlicht in:Trends in pharmacological sciences (Regular ed.) 2014-05, Vol.35 (5), p.237-246
Hauptverfasser: Ruat, Martial, Hoch, Lucile, Faure, Hélène, Rognan, Didier
Format: Artikel
Sprache:eng
Schlagworte:
Advanced Basic Science
Animals
bias agonism
cancer
Hedgehog
Hedgehog Proteins
Hedgehog Proteins - metabolism
Humans
Life Sciences
Ligands
Molecular Targeted Therapy
neurodegenerative disease
Neurons and Cognition
Receptors, G-Protein-Coupled
Receptors, G-Protein-Coupled - agonists
Receptors, G-Protein-Coupled - antagonists & inhibitors
Receptors, G-Protein-Coupled - metabolism
Signal Transduction
Smoothened Receptor
stem cell
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Beschreibung
Zusammenfassung:Highlights • Smo antagonists have potential for cancer therapy. • Positive modulators of Smo may also be therapeutics. • Models of canonical and noncanonical Hedgehog signaling modulation by Smo ligands are presented. • The three-dimensional structure of Smo provides ligand design perspectives.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2014.03.002