Mucosal co-immunization of mice with recombinant lactococci secreting VapA antigen and leptin elicits a protective immune response against Rhodococcus equi infection

Highlights ► Lactococcus lactis (LL) as a mucosal vaccine delivery vector against rhodococcosis. ► L. lactis for efficient production and secretion of Rhodococcus equi VapA antigen. ► Immune response and protection in mice after oral or nasal inoculations were assessed. ► Co-immunization of LL secre...

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Veröffentlicht in:	Vaccine 2011-12, Vol.30 (1), p.95-102
Hauptverfasser:	Cauchard, S, Bermúdez-Humarán, L.G, Blugeon, S, Laugier, C, Langella, P, Cauchard, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycetales Infections - prevention & control Adjuvants, Immunologic Administration, Mucosal Agricultural sciences Allergy and Immunology Animals antigens Applied microbiology bacteria Bacterial Load Bacterial Proteins - genetics Bacterial Proteins - immunology Bacterial Vaccines - administration & dosage Bacterial Vaccines - immunology Bacteriology Biological and medical sciences Cytokines Cytokines - secretion Drug Carriers Female foals Fundamental and applied biological sciences. Psychology Genes Immune response Immune system Immunization immunocompromised population immunomodulators interferon-gamma interleukin-4 intragastric administration intranasal administration intravenous injection Lactococcus Lactococcus lactis Lactococcus lactis - genetics Leptin Leptin - genetics Leptin - secretion Leukocytes, Mononuclear - immunology Life Sciences liver Liver - microbiology Mice Mice, Inbred BALB C Microbiology Miscellaneous Mucosal pathogens Pneumonia Proteins Rhodococcus Rhodococcus equi Rhodococcus equi - immunology spleen Spleen - immunology Spleen - microbiology splenocytes Studies Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology VapA virulent strains
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Beschreibung
Zusammenfassung:	Highlights ► Lactococcus lactis (LL) as a mucosal vaccine delivery vector against rhodococcosis. ► L. lactis for efficient production and secretion of Rhodococcus equi VapA antigen. ► Immune response and protection in mice after oral or nasal inoculations were assessed. ► Co-immunization of LL secreting VapA and leptin induced a protective immune response.
ISSN:	0264-410X 1873-2518 0264-410X
DOI:	10.1016/j.vaccine.2011.10.026