Diastereospecific synthesis of new 4-substituted l-theanine derivatives

Diastereospecific synthesis of new 4-substituted l-theanine derivatives

Considering the biological activity of l-theanine as a potent agonist of NMDA receptors, impacting on glutamatergic synapse activity, we have developed an asymmetric synthesis of new enantiomerically pure 4-substituted l-theanine derivatives. The key step is a stereospecific alkylation on a previous...

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Veröffentlicht in:Tetrahedron: asymmetry 2014-04, Vol.25 (8), p.690-696
Hauptverfasser: Sebih, Fatiha, Bellahouel, Salima, Rolland, Marc, Derdour, Aicha, Martinez, Jean, Rolland, Valérie
Format: Artikel
Sprache:eng
Schlagworte:
Chemical Sciences
Organic chemistry
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Zusammenfassung:Considering the biological activity of l-theanine as a potent agonist of NMDA receptors, impacting on glutamatergic synapse activity, we have developed an asymmetric synthesis of new enantiomerically pure 4-substituted l-theanine derivatives. The key step is a stereospecific alkylation on a previously synthesized and correctly protected (S)-pyroglutamate.
ISSN:0957-4166
1362-511X
0957-4166
DOI:10.1016/j.tetasy.2014.03.016