First substoichiometric version of the catalytic enantioselective addition of an alkyllithium to an aldehyde

First substoichiometric version of the catalytic enantioselective addition of an alkyllithium to an aldehyde

A substoichiometric enantioselective version of the extremely fast nucleophilic addition of Alk-Li to RCHO is made possible thanks to a thorough analysis of the aggregation phenomena involved in the reaction: calculated quantities of LiCl must be added to the medium at the right time to keep the cat...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2011-09, Vol.47 (35), p.9915-9917
Hauptverfasser: Lecachey, Baptiste, Fressigné, Catherine, Oulyadi, Hassan, Harrison-Marchand, Anne, Maddaluno, Jacques
Format: Artikel
Sprache:eng
Schlagworte:
Agglomeration
Aldehydes
Catalysis
Catalysts
Chemical Sciences
Mathematical analysis
Organic chemistry
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Beschreibung
Zusammenfassung:A substoichiometric enantioselective version of the extremely fast nucleophilic addition of Alk-Li to RCHO is made possible thanks to a thorough analysis of the aggregation phenomena involved in the reaction: calculated quantities of LiCl must be added to the medium at the right time to keep the catalytic cycle running.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc13513a