The total synthesis of (+/-)-fortucine and a revision of the structure of kirkine

The total synthesis of (+/-)-fortucine and a revision of the structure of kirkine

The total synthesis of the natural product fortucine relies on a radical cascade process initiated by the generation of a nitrogen-centered (amidyl) radical (see picture). The procedure is concise, and tin-free, as well as stereo- and regioselective. This synthesis has enabled the correction of the...

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Veröffentlicht in:Angewandte Chemie International Edition 2008, Vol.47 (8), p.1436-1438
Hauptverfasser: Biechy, Aurélien, Hachisu, Shuji, Quiclet-Sire, Béatrice, Ricard, Louis, Zard, Samir Z.
Format: Artikel
Sprache:eng
Schlagworte:
Chemical Sciences
Organic chemistry
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Zusammenfassung:The total synthesis of the natural product fortucine relies on a radical cascade process initiated by the generation of a nitrogen-centered (amidyl) radical (see picture). The procedure is concise, and tin-free, as well as stereo- and regioselective. This synthesis has enabled the correction of the structure of kirkine, and the strategy represents a general and rapid entry into the galanthan framework.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200704996