99mTc-(Me)FGCDEVD, a potential tracer for apoptosis detection

99mTc-(Me)FGCDEVD, a potential tracer for apoptosis detection

(Me)FGC(Bz)DEVD was radiolabeled with technetium-99m in high yield. This tracer was preferentially accumulated in apoptotic cells in the in vitro studies. Tumor uptake occurred in vivo after cisplatin injection due to the apoptosis induction, which not observed in the untreated tumors. Therefore, 99...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2013-03, Vol.23 (5), p.1375-1378
Hauptverfasser: Bohn, Pierre, Mouchard, Florian, Rouvet, Jean, de Boisgrollier, Anne-Caroline, Vera, Pierre
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Caspase-3
Diagnosis agents
Technetium-99m
Tumor
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Zusammenfassung:(Me)FGC(Bz)DEVD was radiolabeled with technetium-99m in high yield. This tracer was preferentially accumulated in apoptotic cells in the in vitro studies. Tumor uptake occurred in vivo after cisplatin injection due to the apoptosis induction, which not observed in the untreated tumors. Therefore, 99mTc-(Me)FGCDEVD is a potential tracer for apoptosis detection.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2012.12.088