Probing the mobility of ibuprofen confined in MCM-41 materials using MAS-PFG NMR and hyperpolarised-Xe-129 NMR spectroscopy

The continuous-flow hyperpolarised (HP)-Xe-129 NMR and magic angle spinning-pulsed field gradient (MAS-PFG) NMR techniques have been used for the first time to study the distribution and the dynamics of ibuprofen encapsulated in MCM-41 with two different pore diameters.

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Bibliographische Detailangaben
Veröffentlicht in:	Physical chemistry chemical physics : PCCP 2013, Vol.15 (43), p.18805-18808
Hauptverfasser:	Guenneau, Flavien, Panesar, Kuldeep, Nossov, Andrei, Springuel-Huet, Mari-Anne, Azais, Thierry, Babonneau, Florence, Tourne-Peteilh, Corine, Devoisselle, Jean-Marie, Gedeon, Antoine
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Sciences Galenic pharmacology Life Sciences Material chemistry or physical chemistry Pharmaceutical sciences Theoretical and
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Beschreibung
Zusammenfassung:	The continuous-flow hyperpolarised (HP)-Xe-129 NMR and magic angle spinning-pulsed field gradient (MAS-PFG) NMR techniques have been used for the first time to study the distribution and the dynamics of ibuprofen encapsulated in MCM-41 with two different pore diameters.
ISSN:	1463-9076 1463-9084
DOI:	10.1039/c3cp52695j