Study of genotoxic, antigenotoxic and antioxidant activities of the digallic acid isolated from Pistacia lentiscus fruits

The digallic acid obtained from the fruit Pistacia lentiscus exhibits an inhibitory activity against nitrofurantoine and B[ a]P induced genotoxicity when tested by the SOS chromotest bacterial assay system in the presence of Escherichia coli PQ37 strain. The antioxidant activity of the tested compou...

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Veröffentlicht in:	Toxicology in vitro 2010-03, Vol.24 (2), p.509-515
Hauptverfasser:	Bhouri, Wissem, Derbel, Safa, Skandrani, Ines, Boubaker, Jihed, Bouhlel, Ines, Sghaier, Mohamed B., Kilani, Soumaya, Mariotte, Anne M., Dijoux-Franca, Marie G., Ghedira, Kamel, Chekir-Ghedira, Leila
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigenotoxic effect Antimutagenic Agents - chemistry Antimutagenic Agents - pharmacology Antioxidant capacity Antioxidants Antioxidants - chemistry Antioxidants - pharmacology Benzothiazoles Cell Proliferation - drug effects Depsides - chemistry Digallic acid Dose-Response Relationship, Drug Escherichia coli Escherichia coli - drug effects Free Radical Scavengers Gallic Acid - analogs & derivatives Gallic Acid - chemistry Genotoxic effect Humans K562 Cells Life Sciences Lipid Peroxidation Molecular Structure Mutagens - chemistry Mutagens - toxicity Pistacia - chemistry SOS chromotest Sulfonic Acids - chemistry Superoxides Thiazoles - chemistry Xanthine Oxidase - antagonists & inhibitors
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Zusammenfassung:	The digallic acid obtained from the fruit Pistacia lentiscus exhibits an inhibitory activity against nitrofurantoine and B[ a]P induced genotoxicity when tested by the SOS chromotest bacterial assay system in the presence of Escherichia coli PQ37 strain. The antioxidant activity of the tested compound was determined by its ability to scavenge the free radical ABTS + , to inhibit the xanthine oxidase, involved in the generation of free radicals, and to inhibit the lipid peroxidation induced by H 2O 2 in the K562 cell line. Our results revealed that digallic acid shows an important free radical scavenging activity towards the ABTS + radical (99%) and protection against lipid peroxidation (68%).
ISSN:	0887-2333 1879-3177
DOI:	10.1016/j.tiv.2009.06.024