A new class of β-carboline alkaloid-peptide conjugates with therapeutic efficacy in acute limb ischemia/reperfusion injury

We describe a novel class of β-carboline alkaloid-peptide conjugates that possess both free radical scavenging and thrombolytic activity. These conjugates demonstrate therapeutic efficacy in a rat arterial thrombosis assay, as well as free radical scavenging capacity as evaluated in a PC12 cell survival assay. Our results indicate that β-carboline alkaloid-peptide conjugate 26a exerts a significant protective effect against local and remote organ injury induced by limb I/R injury in the rat. A novel class of β-carboline alkaloid-peptide conjugates that possess both free radical scavenging and thrombolytic activity is described in this manuscript. [Display omitted] ► In this manuscript, we have developed a novel class of β-carboline alkaloid-peptide conjugates. ► These conjugates possess good free radical scavenging and thrombolytic activities. ► Compound 26a exerts a significant protective effect against limb I/R injury in the rat.