Gold-Mediated Synthesis and Functionalization of Chiral Halopyridones

Gold-Mediated Synthesis and Functionalization of Chiral Halopyridones

A rapid and efficient one-step halopyridone synthesis has been developed based on gold-catalyzed cyclization of β-amino-ynone intermediates and halodeauration process.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of organic chemistry 2013-08, Vol.78 (16), p.7809-7815
Hauptverfasser: Nguyen, Khanh Hung, Tomasi, Sophie, Le Roch, Myriam, Toupet, Loïc, Renault, Jacques, Uriac, Philippe, Gouault, Nicolas
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Chemical Sciences
Cyclization
Gold - chemistry
Hydrocarbons, Halogenated - chemical synthesis
Hydrocarbons, Halogenated - chemistry
Molecular Structure
Organic chemistry
Pyridones - chemical synthesis
Pyridones - chemistry
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Beschreibung
Zusammenfassung:A rapid and efficient one-step halopyridone synthesis has been developed based on gold-catalyzed cyclization of β-amino-ynone intermediates and halodeauration process.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo400827b