Fibronectin expression in glioblastomas promotes cell cohesion, collective invasion of basement membrane in vitro and orthotopic tumor growth in mice

Glioblastoma multiforme (GBM) are highly invasive and angiogenic malignancies with a median survival time from diagnosis of

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Veröffentlicht in:	Oncogene 2014-06, Vol.33 (26), p.3451-3462
Hauptverfasser:	Serres, E, Debarbieux, F, Stanchi, F, Maggiorella, L, Grall, D, Turchi, L, Burel-Vandenbos, F, Figarella-Branger, D, Virolle, T, Rougon, G, Van Obberghen-Schilling, E
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1922 631/80/79/1236 631/80/84/2336 Angiogenesis Animals Apoptosis Basement Membrane - cytology Basement membranes Brain cancer Cancer Care and treatment Cell adhesion Cell Adhesion - genetics Cell Biology Cell migration Cell Movement - genetics Cell Proliferation Cell Survival - genetics Cellular Biology Development and progression Extracellular Matrix Fibronectin Fibronectins Fibronectins - biosynthesis Fibronectins - genetics Fibronectins - metabolism Gene Expression Regulation, Neoplastic Genetic aspects Glioblastoma Glioblastoma - metabolism Glioblastoma - mortality Glioblastoma - pathology Glioblastoma multiforme Glioma Growth Human Genetics Humans Identification and classification Immunohistochemistry Integrin alpha5beta1 - metabolism Internal Medicine Ionizing radiation Laminin Life Sciences Medicine Medicine & Public Health Messenger RNA Mice mRNA Neoplasm Invasiveness Neovascularization, Pathologic - genetics Oncology Oncology, Experimental original-article Phenotypes Protein Isoforms - biosynthesis Protein Isoforms - genetics RNA Interference RNA, Small Interfering Spheroids Spheroids, Cellular Tumor cells Tumor Cells, Cultured Tumors
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Zusammenfassung:	Glioblastoma multiforme (GBM) are highly invasive and angiogenic malignancies with a median survival time from diagnosis of
ISSN:	0950-9232 1476-5594
DOI:	10.1038/onc.2013.305