Enantiospecific Synthesis of Pyridinones as Versatile Intermediates toward Asymmetric Piperidines

Enantiospecific Synthesis of Pyridinones as Versatile Intermediates toward Asymmetric Piperidines

The enantiospecific syntheses of pyridinones from amino acids via a gold-catalyzed strategy are reported. Excellent stereocontrol was observed during the cyclization. This approach provides a straightforward tool for further synthetic applications toward piperidines.

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Veröffentlicht in:Organic letters 2011-08, Vol.13 (16), p.4371-4373
Hauptverfasser: Gouault, Nicolas, Le Roch, Myriam, Cheignon, Adèle, Uriac, Philippe, David, Michèle
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acids - chemistry
Chemical Sciences
Cyclization
Molecular Structure
Organic chemistry
Piperidines - chemistry
Pyridones - chemical synthesis
Stereoisomerism
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Zusammenfassung:The enantiospecific syntheses of pyridinones from amino acids via a gold-catalyzed strategy are reported. Excellent stereocontrol was observed during the cyclization. This approach provides a straightforward tool for further synthetic applications toward piperidines.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol201698m