“It stings a bit but it cleans well”: Venoms of Hymenoptera and their antimicrobial potential

[Display omitted] ► Venoms from Hymenoptera display a wide range of functions. ► Venom antimicrobial function is widely distributed within Hymenoptera. ► It probably regulates microbial infections in stinging and stung animals. ► Venom apparatuses constitute hostile living environments for bacteria. ► Venom antimicrobial peptides exhibit versatile activities. Venoms from Hymenoptera display a wide range of functions and biological roles. These notably include manipulation of the host, capture of prey and defense against competitors and predators thanks to endocrine and immune systems disruptors, neurotoxic, cytolytic and pain-inducing venom components. Recent works indicate that many hymenopteran species, whatever their life style, have also evolved a venom with properties which enable it to regulate microbial infections, both in stinging and stung animals. In contrast to biting insects and their salivary glands, stinging Hymenoptera seem to constitute an under-exploited ecological niche for agents of vector-borne disease. Few parasitic or mutualistic microorganisms have been reported to be hosted by venom-producing organs or to be transmitted to stung animals. This may result from the presence of potent antimicrobial molecules in venoms, histological features of venom apparatuses and selective effects of venoms on immune defenses of targeted organisms. The present paper reviews for the first time the venom antimicrobial potential of solitary and social Hymenoptera in molecular, ecological, and evolutionary perspectives.