Absorption of zidovudine in patients with diarrhoea

Many patients with AIDS have gastrointestinal complaints, including the major clinical disorder of chronic diarrhoea. The pharmacokinetics of zidovudine was studied in 9 male patients with HIV infection and diarrhoea to establish whether drug absorption was impaired in them. The peak plasma concentr...

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Veröffentlicht in:European journal of clinical pharmacology 1993-06, Vol.44 (5), p.501-503
Hauptverfasser: Zorza, G, Beaugerie, L, Taburet, A M, Le Quintrec, Y, Singlas, E
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container_issue 5
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container_title European journal of clinical pharmacology
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creator Zorza, G
Beaugerie, L
Taburet, A M
Le Quintrec, Y
Singlas, E
description Many patients with AIDS have gastrointestinal complaints, including the major clinical disorder of chronic diarrhoea. The pharmacokinetics of zidovudine was studied in 9 male patients with HIV infection and diarrhoea to establish whether drug absorption was impaired in them. The peak plasma concentration and AUC after a single oral dose of 200 mg, were the same as those reported in 6 healthy male volunteers (3.1 vs 4.0 mumol.l-1 and 7.2 vs 5.2 mumol.h.l-1, respectively). Since the bioavailability of zidovudine is not particularly impaired, oral zidovudine therapy can be maintained in patients with diarrhoea.
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subjects Acquired Immunodeficiency Syndrome - complications
Acquired Immunodeficiency Syndrome - metabolism
Adult
AIDS/HIV
Biological Availability
Chemical Sciences
Chronic Disease
Diarrhea - complications
Diarrhea - metabolism
Humans
Intestinal Absorption
Male
Middle Aged
Organic chemistry
Zidovudine - antagonists & inhibitors
Zidovudine - pharmacokinetics
title Absorption of zidovudine in patients with diarrhoea
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