Absorption of zidovudine in patients with diarrhoea
Many patients with AIDS have gastrointestinal complaints, including the major clinical disorder of chronic diarrhoea. The pharmacokinetics of zidovudine was studied in 9 male patients with HIV infection and diarrhoea to establish whether drug absorption was impaired in them. The peak plasma concentr...
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Veröffentlicht in: | European journal of clinical pharmacology 1993-06, Vol.44 (5), p.501-503 |
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creator | Zorza, G Beaugerie, L Taburet, A M Le Quintrec, Y Singlas, E |
description | Many patients with AIDS have gastrointestinal complaints, including the major clinical disorder of chronic diarrhoea. The pharmacokinetics of zidovudine was studied in 9 male patients with HIV infection and diarrhoea to establish whether drug absorption was impaired in them. The peak plasma concentration and AUC after a single oral dose of 200 mg, were the same as those reported in 6 healthy male volunteers (3.1 vs 4.0 mumol.l-1 and 7.2 vs 5.2 mumol.h.l-1, respectively). Since the bioavailability of zidovudine is not particularly impaired, oral zidovudine therapy can be maintained in patients with diarrhoea. |
doi_str_mv | 10.1007/BF00315553 |
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The pharmacokinetics of zidovudine was studied in 9 male patients with HIV infection and diarrhoea to establish whether drug absorption was impaired in them. The peak plasma concentration and AUC after a single oral dose of 200 mg, were the same as those reported in 6 healthy male volunteers (3.1 vs 4.0 mumol.l-1 and 7.2 vs 5.2 mumol.h.l-1, respectively). Since the bioavailability of zidovudine is not particularly impaired, oral zidovudine therapy can be maintained in patients with diarrhoea.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF00315553</identifier><identifier>PMID: 8359192</identifier><language>eng</language><publisher>Germany: Springer Verlag</publisher><subject>Acquired Immunodeficiency Syndrome - complications ; Acquired Immunodeficiency Syndrome - metabolism ; Adult ; AIDS/HIV ; Biological Availability ; Chemical Sciences ; Chronic Disease ; Diarrhea - complications ; Diarrhea - metabolism ; Humans ; Intestinal Absorption ; Male ; Middle Aged ; Organic chemistry ; Zidovudine - antagonists & inhibitors ; Zidovudine - pharmacokinetics</subject><ispartof>European journal of clinical pharmacology, 1993-06, Vol.44 (5), p.501-503</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-376f4c7e57e756a19952b351c2aa15966e52c6db251c0a633e4804eb0cb7d9723</citedby><cites>FETCH-LOGICAL-c316t-376f4c7e57e756a19952b351c2aa15966e52c6db251c0a633e4804eb0cb7d9723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8359192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00815135$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Zorza, G</creatorcontrib><creatorcontrib>Beaugerie, L</creatorcontrib><creatorcontrib>Taburet, A M</creatorcontrib><creatorcontrib>Le Quintrec, Y</creatorcontrib><creatorcontrib>Singlas, E</creatorcontrib><title>Absorption of zidovudine in patients with diarrhoea</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>Many patients with AIDS have gastrointestinal complaints, including the major clinical disorder of chronic diarrhoea. The pharmacokinetics of zidovudine was studied in 9 male patients with HIV infection and diarrhoea to establish whether drug absorption was impaired in them. The peak plasma concentration and AUC after a single oral dose of 200 mg, were the same as those reported in 6 healthy male volunteers (3.1 vs 4.0 mumol.l-1 and 7.2 vs 5.2 mumol.h.l-1, respectively). Since the bioavailability of zidovudine is not particularly impaired, oral zidovudine therapy can be maintained in patients with diarrhoea.</description><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Acquired Immunodeficiency Syndrome - metabolism</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Biological Availability</subject><subject>Chemical Sciences</subject><subject>Chronic Disease</subject><subject>Diarrhea - complications</subject><subject>Diarrhea - metabolism</subject><subject>Humans</subject><subject>Intestinal Absorption</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Organic chemistry</subject><subject>Zidovudine - antagonists & inhibitors</subject><subject>Zidovudine - pharmacokinetics</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFLwzAUh4Moc04v3oWeBIXqe0mTNMc5nBMGXvQc0jZlka6ZSTvRv96OjXl68PHx8fgRco3wgADy8WkOwJBzzk7IGDNGU4QMT8l4h1OhJJyTixg_AZArYCMyyhlXqOiYsGkRfdh0zreJr5NfV_ltX7nWJq5NNqZztu1i8u26VVI5E8LKW3NJzmrTRHt1uBPyMX9-ny3S5dvL62y6TEuGokuZFHVWSsullVwYVIrTgnEsqTHDH0JYTktRFXRAYARjNsshswWUhayUpGxC7vbdlWn0Jri1CT_aG6cX06XeMYAcOTK-xcG93bub4L96Gzu9drG0TWNa6_uoJVcU81wN4v1eLIOPMdj6WEbQuzX1_5qDfHOo9sXaVkf1MB_7A2SmbFw</recordid><startdate>19930601</startdate><enddate>19930601</enddate><creator>Zorza, G</creator><creator>Beaugerie, L</creator><creator>Taburet, A M</creator><creator>Le Quintrec, Y</creator><creator>Singlas, E</creator><general>Springer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>19930601</creationdate><title>Absorption of zidovudine in patients with diarrhoea</title><author>Zorza, G ; Beaugerie, L ; Taburet, A M ; Le Quintrec, Y ; Singlas, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-376f4c7e57e756a19952b351c2aa15966e52c6db251c0a633e4804eb0cb7d9723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Acquired Immunodeficiency Syndrome - complications</topic><topic>Acquired Immunodeficiency Syndrome - metabolism</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Biological Availability</topic><topic>Chemical Sciences</topic><topic>Chronic Disease</topic><topic>Diarrhea - complications</topic><topic>Diarrhea - metabolism</topic><topic>Humans</topic><topic>Intestinal Absorption</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Organic chemistry</topic><topic>Zidovudine - antagonists & inhibitors</topic><topic>Zidovudine - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zorza, G</creatorcontrib><creatorcontrib>Beaugerie, L</creatorcontrib><creatorcontrib>Taburet, A M</creatorcontrib><creatorcontrib>Le Quintrec, Y</creatorcontrib><creatorcontrib>Singlas, E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zorza, G</au><au>Beaugerie, L</au><au>Taburet, A M</au><au>Le Quintrec, Y</au><au>Singlas, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Absorption of zidovudine in patients with diarrhoea</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1993-06-01</date><risdate>1993</risdate><volume>44</volume><issue>5</issue><spage>501</spage><epage>503</epage><pages>501-503</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>Many patients with AIDS have gastrointestinal complaints, including the major clinical disorder of chronic diarrhoea. The pharmacokinetics of zidovudine was studied in 9 male patients with HIV infection and diarrhoea to establish whether drug absorption was impaired in them. The peak plasma concentration and AUC after a single oral dose of 200 mg, were the same as those reported in 6 healthy male volunteers (3.1 vs 4.0 mumol.l-1 and 7.2 vs 5.2 mumol.h.l-1, respectively). Since the bioavailability of zidovudine is not particularly impaired, oral zidovudine therapy can be maintained in patients with diarrhoea.</abstract><cop>Germany</cop><pub>Springer Verlag</pub><pmid>8359192</pmid><doi>10.1007/BF00315553</doi><tpages>3</tpages></addata></record> |
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subjects | Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - metabolism Adult AIDS/HIV Biological Availability Chemical Sciences Chronic Disease Diarrhea - complications Diarrhea - metabolism Humans Intestinal Absorption Male Middle Aged Organic chemistry Zidovudine - antagonists & inhibitors Zidovudine - pharmacokinetics |
title | Absorption of zidovudine in patients with diarrhoea |
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